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miss durbz online store reviews and information. We use the data in order to present our
research hypotheses to other researchers regarding the impact and development of
specific diseases, and to inform research into potential treatments and development of
new medications.
Conclusion {Sec12}
==========
A number of potential treatments for
IBD remain unclear, including new medications. This has been recently explored with the
aim of better understanding the pathogenesis of IBD. However, limited knowledge of how
to improve treatment and make a meaningful impact is still required for clinical
management. The present research was limited to a single trial (Trial Number T-106820,
NCT03048681) that investigated the effects of a new drug called fluoxetine and its
metabolites. With the present study, we have shown that fluoxetine has the most
promising effects to treat IBD, and the novel metabolite fluoxetine inhibits in both
the central nervous system and the gastrointestinal tract. The central nervous system
has a critical role in the production and function of neurotransmitters,
neurotransmitters, and neuropeptides, and this central nervous system is the key driver
of IBD. Furthermore, our findings suggest that fluoxetine will improve IBD
symptomatology. Thus, the study needs to be replicated, conducted, and validated to
assess the overall efficacy of fluoxetine, and the overall effects and harms of the
proposed treatment. We will further expand our in-depth understanding of the mechanism
by which fluoxetine could contribute to the development of novel antidepressants as
well as to further investigate potential therapeutic effects. Furthermore, in the
future, it would also be necessary to determine the potential mechanism by which
fluoxetine causes adverse effects.
Supplementary
information
=========================
{Sec13}
Supplementary Materials
**Publisher's
note:** Springer Nature remains neutral with regard to jurisdictional claims in
published maps and institutional affiliations.
Supplementary
information
=========================
**Supplementary information** accompanies this
paper at 10.1038/s41598-019-41823-3
This work was supported by grants from the
Foundation for the National Institutes of Health (T35CA133500), a grant from the
Wellcome Trust (to A.T.), and the University of Minnesota Comprehensive Cancer Center
of Excellence (T32CA123700). The contents of this manuscript are solely the
responsibility of the authors and do not represent the official views of the Department
of Health and Human Services. The funding body has no role in the conduct of the study;
no funding organization has any role in the collection, analysis, and interpretation of
data; in the writing of the manuscript; or in the decision to submit this manuscript
for publication.
D.W. and A.T. designed the study. D.W., A.T., A.P., and S.C.
performed the animal study, and D.W. interpreted and edited the manuscript. D.W., A.P.,
and S.C. analyzed data and prepared the manuscript. D.W., A.P., S.C., A.M.T., and
A.M.W. contributed to the discussion and design of the study. D.W. wrote the
manuscript. All authors have read and approved the final manuscript.
The datasets used
in this study are available from the corresponding author on reasonable request. The
datasets supporting the results of this study are available from the corresponding
author on reasonable request.
Competing Interests {FPar1}
===================
The
authors declare no competing interests.
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Barry Larkin
A new series from the London Evening Standard about
the Great Western Empire, published by the Daily Mirror in December, has been released.
Barry Larkin, the acclaimed BBC news anchor for the past 20 years, will cover the
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Read Barry Larkin's full review at:
http://www.bbc.co.uk/news/health-uk-628823
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